Isocyanate and Health 過去・現在・未来
シンポジウム
２０１３年 ４月３・４日 メリーランド州ポトマック
発表タイトル集（プログラムブック）
P.11
Opening Remarks & Welcome
Polyurethane Chemistry and Product: Past, Present and Future
Worker Exposure Issues: A Challenge To Reserchers
Consumer Exposures To Isocyanates: What Do We Know? How Can Occupational
Exposures Inform Us? And Do We Need To Learn?
Pathways To Pathogenesis: Toxicology & Animal Models
Isocyanate Biomarkers
Concept Applications & Facillitated Discussion
A Hypothesis-Based Weight-Of-Evidence Approach To Evaluate the Human Carcinogennicity
of isocyanates
Stream 1: Worker and Exposure Issues
Stream 2:Toxicity Testing/Animal Models/Biomarkers & Human Cancer Risk
Exposure to 4,4'-Methylenediphenyl Diisocianate (MDI) and/or Polyurethanes: Asthma and Cancer Risk?
Respiratory Sensitization Thresholds for Diisocyanates in Animal Models
Induction of the inflammatory protein autotaxin a new hypothesis for a
mechanism behind airways disease caused by aromatic diisocyanates
Monoclonal Antibodies (mAbs) to Methylene Diphenyl diisocyanate (MDI) and
Toluene Diisocyanate (TDI) Conjugated Protein: Reseach and Potential Biomonitoring
Applications.
Anti-Methylene Diphenyl Diisocyanate (MDI) Murine Monoclonal (IgG) Antibodies
Enrichment and measurement of a signature MDI human serum albmin peptide
adduct
Inerferon Gamma Promoter is Hypermethlated in Blood DNA from Aorkers with
Confirmd Diisocyanate Asthma
Environmental Exposure/Monitoring
Determination of Gas Phase Isocyanate Using Proton Transfer Reaction Mass Spectrometry
Dry sampler for airborne isocyanates
Measureing Total Reactive Isocyanate Group Using 1,8-Diaminonaphthalene
(DAN)
Particles size fractionated sampler for isocyanates
Isocyanate Aerosols from Thermal Degradation of polymers
Determination of Residual Toluene Diisocyanate (TDI) from Flexible Polyurethane
Foam
Development of a skin exposure dosimeter for Methylene Diphenyl Diisocyanate
(MDI)
Occupation Health Surveillance/Management & Respiratory Epidemiology
and Disease
Changes in Workers' Compensation Claims for Diisocyanate-Induced Asthma, 1980-2007 in Ontalio, Canada, Compared with other Causes of Occupational Asthma
A dynamic population-based model for the development of work related respiratory
health effects among car body repair shop workers
Are U.S. Comanies that Use Isocyanates Providing Medical Surveillance?
Overview of an Industry-wide Study of Toluene Diisocyanate (TDI) Exposure
and the Development of Occupational Asthma
Methylene-Diphenyl Diisocyanate (MDI) usage, Exposure and health outcomes
among polyurethane spray foam insulators in the construction industry
Immonologic Markers of isocyanate respiratory disease: Are they clinically
important?
PLENARY PROGRAM BY SPEAKER (p.15)
Current Issues in Measurement of Dermal Exposure to Isocyanates
Worker Exposure Issues: A Challenge to Reserchers
Polyurethane Chemistry and Products: Past, Present and Future
A Hypothesis-Based Weight-Of-Evidence Approach To Evaluate the Human Carcinogennicity of isocyanates
Health and Hazard Surveillance for Isocyanate Exposed Workers
Concept Applications & Faciliated Discussion
Isocyanate Biomarkers
Consumer Exposures to Isocyanate: What Do We Know? How Can Occupational
Exposures Inform Us? And Do We Need To Learn?
Human Health Effect of Isocyanate: Clinical Spectrum, Pathogenesis, Epidemiology
and Outcome
Current Issues in Measurement of Airborne Isocyanates
Pathways To Pathogenesis: Toxicology & Animal Models
Workers and Consumer Exposure Issues p.16
Occupational Exposure to Isocyanates and Use of Respiratory Protection in the Car Repair Industry; A Baseline Exposure Assessment
Effectiveness of Educational and Behavioral Interventions to Reduce Isocyanate
Exposure in the Auto Body Repair and Refinishing Industry; A Cluster-Randomaized
Controlled trial
Accuracy of Toxicological Information on Material Safety Data Sheets for
Respiratory Tract Sensitizer and Asthmagens Used in Workplaces in Canada
Risk assessment for consumer exposure to toluene Diisocyanate (TDI) derived
from polyurethane flexible foam
Inseption Cohort Study of Workers Exposed to Toluene Diisocyanate at a
Polyurethane Foam
Communities near toluene diisocyanate sources: an investigation of exposure
and health
A Case Series of Families with Symptoms Associated with Home Polyurethane
Spray Foam Insulation
Determination of aromatic amines in aqueous of polyurethane foam
Abstruct Title P.17
Risk assessment for consumer exposure to toluene Diisocyanate (TDI) derived from polyurethane flexible foam
Interferon Gamma Promoter is Hypermethylated in Blood DNA from Workers with Confirmed Diisocyanate Asthma
Immunologic markers of isocyanate respiratory disease: Are they clinically
important?
Induction of the inflammatory protein autotaxin a new hypothesis for a
mechanism behind airways disease caused by aromatic diisocyanates
Respiratory Sensitization Threshhold for Diisocyanates in Animal Models
Overview of an Industry-wide Study of Toluene Diisocyanate (TDI) Exposure and the Development of Occupational Asthma
Determination of Aromatic Amines in Aqueous Extracts of Polyurethane Foam
Inception Cohort Study of Workers Exposed to Toluene Diisocyanate at a
Polyurethane Foam Factory: One Year Follow-up
Development of a Skin Exposure Dosimeter for Methylen Diphenyl Diisocyanate (MDI)
Determination of gas phase Isocyanate using proton transfer reaction mass
spectrometry
Dry sampler for airborne isocyanates
Effectiveness of Educational and Behavioral Interventions to Reduce Isocyanate
Exposure in the Auto Body Repair and Refinishing Industry: A Cluster-Randomized
Controlled Trial
Enrichment and measurement of a signature MDI human serum albmin peptide adduct
Accuracy of Toxicological Information on Material Safety Data Sheets for
Respiratory Toract Sensitizers and Asthmagens Used in Workplaces in Canada
p.17
A dynamic population-based model for the development of work related respiratory health effects among car body repair shop workers
A Case Series of Families with Symptoms Associated with Home Polyurethane Spray Foam Insulation
Are U.S. Comanies that Use Isocyanates Providing Medical Surveillance?
Exposure to 4,4'-Methylenediphenyl Diisocianate (MDI) and/or Polyurethanes: Asthma and Cancer Risk?
Monoclonal Antibodies (mAbs) to Methylene Diphenyl diisocyanate (MDI) and
Toluene Diisocyanate (TDI) Conjugated Protein: Reseach and Potential Biomonitoring
Applications.
Particles size fractionsated sampler for isocyanates
Isocyanate Aerosols from Thermal Degradation of Polymer
Measuring Total Reactive Isocyanate Group based on 1,8-Diaminonaphthalene
(DAN)
Changes in Workers' Compensation Claims for Diisocyanate-Induced Asthma, 1980-2007 in Ontalio, Canada, Compared with other Causes of Occupational Asthma
Occupational Exposure to Isocyanates and Use of Respiratory Protection in the Car Repair Industry; A Baseline Exposure Assessment
Determination of Residual Toluene Diisocyanate (TDI) from Frexible Polyurethane
Foam
Communities Near Toluene Diisocyanate Sources: An Investigation of Exposure and Health
Anti-Methylene Diphenyl Diisocyanate (MDI) Murine Monoclonal (IgG) Antibodies
Methylene-Diphenyl Diisocyanate (MDI) usage, Exposure and health outcomes
among polyurethane spray foam insulators in the construction industry
Poster Presentation
P.23
Cross Sectional Survey of Workers Exposed to Alphatic Diisocyanates Using
Detailled Respiratory Medical Histry
A dynamic population-based model for the development of work related respiratry
health effects among car body repair shop workers
Free Infomational Training DVD's on "Safe Handling of Toluene Diisocyanates"
and "Safe Handling of Diphenylmethane Diisocyanate"
Isocyanate-based Spray- On Truck Bed Liner Health and Safety Consideration
CPI Product Stewardship Literature
Isocyanate - CPI SPF Health and Safety Outreach and Training
Polyurethane Foam - Process Flow
Polyurethane Foam - Management Systems
Polyurethane Foam - Controls
Poreurethane Foam - Communication
P.22
Introduction of the inflammatory protein autotaxin a new hypothesis for
a mechanism behind airways disease caused by aromatic diisocyanates
Enrichment and measurement of a signiture MDI human serum albmin peptide
adduct
Respiratory Tract Dosimetry of Hexamethylene Diisocyanate in Rats and Humans
Respiratory Sensitization Threshhold for Diisocyanates in Animal Models
Isotriamine, a Biomarker of isocyanate Exposure in Automotive Spray Painters
Rat Lung Tumors Following Inhalation Exposures to Methylenediphenyldiisocyanate
(MDI) implications for Human Health
Hypothesis-Based Weight0fo-Evidence Evaluation of the Human Carcinogenicity
of Toluene Diisocyanate
Exposures to 4,4 Methylene Diphenyl Diisocyanate (MDI) and/or Polyurethanes:
Asthma and Cancer Risk?
A Survey of The Incidence of Occupational Asthma Among Flexible Polyurethane
Foam Slabstock Plants
Are Diisocyanate Occupational Asthma cases Declining
P.21
Anti-Methylene Diphenyl Diisocyanate (MDI) Murine Monoclonal (IgG) Antibodies
Percutaneous absorption of 4,4-methylene diphenyl diisocyanate in humans
A methodology proposal to use a Multiple Model data fusion (MMDF) framework
and tequeniques for systems biology and tpxisocolgical evaluations ansd
identification of biomarkers of complex Isocyanate Clusters of Chemicals
Characterization of diisocyanate haptenation of serum albumin by multiplexed
tandem mass spectrometry
Characterization of Methylene Diphenyl Diisocyanate Haptenated Human Serum
Albumin and Hemoglobin
Monoclonal Antibodies (mAbs) to Methylene Dipheyl diisocyanate (MDI) and
Toluen Diisocyanate (TDI) Conjugated Protein: Research and Potential Biomonitoring
Applications.
Interferon Gamma Promoter is Hypermethylated in Blood DNA from Workers
with Confirmed Diisocyanate Asthma
P.20
Web-Based Data Collection System Used for Industry-wide Study of Toluene Diisocyanate (TDI) Exposure and the Development of Occupational Asthma
Developing Guidance for the Diagnosis
and Menagement of Work-related Asthma (WRA): The ACOEM pracice Guidelines
Early diagnosis of occupational asthma and exposure dontrol: results from
a stepped care program in Montreal targeted at auto body shop workers
MHC class I and dlass II gene variants are associated with diisocyanate-induced
asthma
Are U.S. Comanies that Use Isocyanates Providing Medical Surveillance?
Diisocyanates and Work-related Asthma: Finding from Californiaq, Massachusetts,
Michigan, and New Jersey, 1993-2008
Methylene-Diphenyl Diisocyanate (MDI) usage, Exposure and health outcomes among polyurethane spray foam insulators in the construction industry
Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum
Levels of HDI-Specigic IgG
p.19
Medical Devices and Products as Potential Sources of isocyanate Skin Exposure
in Neonatal Infants: A Qualitative Assessment
Measuring Total Reactive Isocyanate Group based on 1,8-Diaminonaphthalene
(DAN)
Development of a Skin Exposure Dosimeter for Methylen Diphenyl Diisocyanate (MDI)
Determination of Residual Toluene Diisocyanate (TDI) from Flexible Polyurethane Foam
Dry sampler for airborne isocyanates
Particle size fractionated sampler for isocyanate
Isocyanate Aerosols from Thermal Degradation of polymers
The Development of Testing Methods for Characterizing Emissions & Sources
of Exposures from Polyuretane Products
Educational Exhibits
Free Informational Training DVD's on "Safe Handling of Toluen Diisocyanate"
and "Safe Handling ofDiphenylmethane Diisocyanate"
Life-Threatening Interstitial Pneumonia in a Worker Involved in Polyurethane
Spray Floor Insulation
Cross Section Survey of Workers Exposed to Aliphatic Diisocyanates Using
Detailed Resiratory
Medical Hisotry
A Survey of the Incidence of Occupational Asthma Among Flexible Polyurethane
Foam Slabstock Plants
A Novel Analytical Scheme for Measuring Total Reactive Isocyanate Group
based on 1,8-Diaminonaphthalene
Isotriamine, a Biomarker of Isocyanate Exposure in Automotive Spray Painters
A Methodology Proposal to use a Multiple Model Data Fusion (MMDF) Framework
and Techniques for Systems Biology and Toxicological Evaluations and Identification
of Biomarkers of Complex Isocyanate Cluster of Chemical
Characterization of Diisocyanate Haptenation of Serum Albumin by Multiplexed
Tandem Mass Spectrometory
Isocyanate-Developing ASTM Standerds for Measuring Potential Methylenediphenyl
Diisocyanate (MDI) Emissions from Spray Poyurethane Foam (SPF) Insulation
Products Designed for On-site Application in Buildings
Characterizing Exposures to Diisocyanates Used in Spray Polyurethane Foam
Insulation (SPFI) and Other Polyurethane Product
Adsorption Efficiency of Respirator Filters Cartridges For Isocyanates
Biologiacal Monitoring for Isocyanates in the UK
Characterizing Relative Exposures to Isocyanates across the Lifecycle of
Polyurethane Products